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State of the evidence 2017: an update on the connection between breast cancer and the environment

Janet M. Gray, Sharima Rasanayagam, Connie Engel and Jeanne Rizzo

 

 

Gray et al. Environmental Health 2017

 

 

Singly and in combination, these toxicants may have contributed significantly to the increasing rates of breast cancer observed over the past several decades. Exposures early in development from gestation through adolescence and early adulthood are particularly of concern as they re-shape the program of genetic, epigenetic and physiological processes in the developing mammary system, leading to an increased risk for developing breast cancer. In the 8 years since we last published a comprehensive review of the relevant literature, hundreds of new papers have appeared supporting this link, and in this update, the evidence on this topic is more extensive and of better quality than that previously available

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